Ion chromatography (IC) is a key analytical technique used for the separation and analysis of components in matrices ranging from solid to liquid to gaseous. Metrohm has led advancements in IC for more than a quarter century, introducing the first compact ion chromatographs and modular systems, as well as intelligent, self-monitoring ion chromatographs. Automated sample preparation through dilution, ultrafiltration, dialysis, neutralization, matrix, elimination and pre-concentration enables you to collect accurate data in record time. When combined with our application support and industry-leading warranties, Metrohm provides you with the most reliable and intuitive ICs.
Even small concentrations of an impurity can cause significant side effects. The azide used in the synthesis of the antihypertensive irbesartan can be detected in trace amounts as an impurity in the product. The U.S. Pharmacopeia recommends ion chromatographic azide determination after direct injection in accordance with USP. The azide determination is more selective, more sensitive, and, most importantly, faster when using Inline Matrix Elimination, whereby the interfering pharmaceutical matrix is separated from the target analyte already during the sample preparation step. Metrohm IC has much more to offer! See document "Impurity profiling with ion chromatography".
