Cellulose Acting as a Catalyst for Dissolution
Modified Sodium Carboxy Methyl Cellulose
Crosslinked Sodium Carboxy Methyl Cellulose.
Introduction :As importance of bio-availability and fast disintegration of pharmaceutical tablet is realised, awarness for super-disintegrants in pharmaceutical tablet formulation is also increasing . Superdisintegrant viz. Sodium Starch Glycollate was also introduced by Maple Biotech Pvt Ltd. in year 1991, which was appreciated in quality and performance by pharmaceutical industry . Although quest for superior quality superdisintegrant was not over . Superdisintegrant with better stability and superior performance at high tablet hardness level was sought and Maple Biotech's R & D department developed the product Crosslinked Sodium Carboxy Methyl Cellulose which is bearing brand name Cel-Ca-Dissol.
Properties : Cel-Ca-Dissol is white or creamish white in colour and chemically it is cross-linked Sodium Carboxy Methyl Cellulose with very high degree of purity . Very hard tablets where other superdisintegrants do not perform well Cel-Ca-Dissol performs very much satisfactorily. Quantity to be used in pharmaceutical formulation is very less. Cel-Ca-Dissol is required almost half the amount of other brands of Crosslinked Sodium Carboxy Methyl Cellulose to acheive similiar performance of tablet dissolution
Specifications of Cel-Ca-Dissol
Colour : White
Sodium Chloride & Sodium Glycollate : Max. 0.5 %
pH ( 1% aqueous dispersion ) : 5.0 to 7.0
Heavy Metals : Max 10 ppm .
Sulphated Ash : 14 to 28 %
Settling Volume (1.5 gm. in 100 ml.) : 10 to 30 ml.
Advantages of Croscarmellose Sodium
