CelCradle™ is a disposable bioreactor capable of high density cell culture for protein expression, virus and monoclonal antibody production.
It is designed based on the concept of bellow-induced intermittent flow of media and air through porous matrices, where cells reside.
This provides a low shear, high aeration, and foam-free culture environment.
Fully Stainless Steel – SS304L Pre-sterilized, ready-to-use, disposable Low shear stress, foam-free, no O2 limitation Large surface area: pne CelCradle™ bottle has a specific surface area of 15,000 cm2, comparable to 20 – 30 roller bottles.
Compact design: fits in 6ft3 CO2 incubator Controlled by Esco Sentinel Gold Capacity to produce hundreds of milligrams to several grams of secreted proteins or monoclonal antibodies per month in four bottles
Few parameters for easy optimization Choice of batch, fed-batch, or perfusion culture modes
Scalability by directly multiplying number of bottles used
Compatible with most serum-free media
Specially treated micro carrier surface to grow most anchorage-dependent cells and allow easy harvest of whole cells, cell components or secreted proteins
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